Table 2.
Key enriched pathways for the multi-genomic Bayesian tensor factors.
| BTF | Key pathways | NES | p-value | FDR | Key pathway genes |
|---|---|---|---|---|---|
| 1 | Chemokine signaling pathway | 1.57 | 0.0059 | 0.25 | CXCL5|CXCL1|CCL8|CXCL3|CCL13|PRKX|CXCL6|CCL8|CXCL2|CCL5|CCL2|CCL4|CCL25|ADCY3|GNB4|CCL3|RAC2|RELA|PPBP|CCL23|CCL24|ROCK2|ITK |
| 2 | Cytokine receptor interaction | 1.96 | <0.001 | <0.001 | CCL21|CCL19|CCL14|CXCL14|IL17B|CXCL2|CD40LG|CXCL12|TSLP|TNFSF11|CNTFR|CXCL1|CCL5|TPO|CCL23|IL21R|CCL13|ACVRL1|IL12B|CCL11|PDGFRB|CCL2|CD70|CCL16|CCL18|CCL4|IL7|CSF1R|TNFSF4|IL11RA|CXCL6|CTF1|CXCL3|EPOR|EDA2R|CCL3 |
| 3 | Huntington's disease | −2 | <0.001 | 0.0029 | DNALI1|DNAI1|COX7B|CREB3|CLTA|NDUFS3|UQCRC1|COX6A1|AP2S1|NDUFA2|COX5B|NDUFA7|BBC3 |
| 4 | Natural killer cell mediated cytotoxcity | −2 | <0.001 | 0.0024 | IFNA7|KIR2DL1|NCR1|ULBP1|ULBP2|RAC2|ZAP70|CD244|VAV1|KIR2DL4|CD48|GZMB| |
| 5 | Hematopoietic cell lineage | 2.13 | <0.001 | <0.001 | MS4A1|CR2|FCER2|CD5|CD2|CR1|CD1E|CD1B|CD1C|CD1D|CSF1R|CD33|IL7|TPO|CD1A|IL5RA |
| 6 | Starch and sucrose metabolism | −1.93 | 0.0029 | 0.03 | PYGL|UGT2B10|UGT2B11 |
| 7 | Cell cycle | −1.83 | 0.0047 | 0.08 | CCNA1|ANAPC10|CCND2|CDKN1B|ANAPC7|CDC23|PTTG1|CDK1|CDC25C|ESPL1 |
| 8 | Retinol metabolism | 1.76 | 0.0063 | 0.16 | ADH1C|UGT2B11|UGT2B10|UGT1A6|UGT1A7|UGT1A9|RPE65|CYP1A2|CYP2C19|ADH4|UGT1A8|UGT2A1|ALDH1A1 |
| 9 | Steroid hormone biosynthesis | −1.65 | 0.0011 | 0.05 | UGT2B11|CYP7B1|HSD17B7|CYP11B2|CYP11B1 |
| 10 | Leukocyte trans endothelial migration | 1.92 | <0.001 | 0.04 | MSN|CXCL12|CYBA|CYBB|JAM2|MYL2|CTNND1|SIPA1|CLDN22 |
| 11 | VEGF signaling pathway | 1.63 | 0.02 | 0.22 | PTGS2|PLA2G10|CHP2|PLA2G4E|PLA2G2F |
| 12 | Olfactory transduction | −1.76 | <0.001 | 0.10 | OR51V1|OR2W1|OR12D2|OR2T5|OR7D4|OR10G7|OR2A2|PRKX|OR10G8|OR1I1|GUCA1C|OR14J1|OR10H5|OR11A1|OR13J1|OR10C1| |
| 13 | Oocyte meiosis | 1.46 | 0.05 | 0.39 | ADCY8|MOS|YWHAQ|SMC1A|CHP2 |
| 14 | Drug metabolism cytochrome | 2.32 | <0.001 | <0.001 | GSTM1|UGT2B11|UGT2B10|GSTO2|MAOA|GSTM3|UGT1A7|ADH1C|UGT1A6|ALDH1A3|UGT1A9|UGT1A10 |
| 15 | Endocytosis | 1.81 | 0.0048 | 0.09 | DNAJC6|CBLC|PSD2|CHMP4A|RAB11FIP4|EHD1|HSPA1A|RET|ARF6|CSF1R|VPS37C|AP2S1|RAB11B|ARAP3|RAB5A |
| 16 | Antigen processing and presentation | 1.47 | <0.001 | 0.0097 | CD74|HSPA1A|PSME1|HSPA1B|PSME2|NFYB|HSPA2 |
| 17 | Metabolism of Xenobiotics by cytochrome | 2.16 | <0.001 | 0.0010 | UGT2A1|CYP2C9|UGT1A7|UGT1A3|UGT1A5|UGT1A8|GSTM1|UGT1A10|GSTA3|UGT1A4|CYP1A2|UGT1A1|UGT1A9|UGT1A6|CYP2F1|AKR1C4|CYP2C18|GSTA5|ADH4|CYP2C19|UGT2B10|ALDH1A3 |