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. 2022 May 13;13:874487. doi: 10.3389/fgene.2022.874487

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Copyright © 2022 Liu, Hong, Lian, Xiao, Li, Diao and Zeng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional enrichment analysis of the DEGs between normoweight and overweight/obese PCOS patients. (A) Statistics of KEGG pathway enrichment. The bubble size represents the count of genes annotated by the differential gene, and the color corresponds to the p-value. (B,C) GSEA enrichment score curves. (D) IL-17 signaling pathway constructed by KEGG. Red boxes represent upregulated genes in normoweight PCOS samples, and green boxes represent downregulated genes in normoweight PCOS samples. (E) Validation of the mRNA expression level by qRT-PCR.