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. 2022 May 13;10:833579. doi: 10.3389/fcell.2022.833579

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Copyright © 2022 Wang, Xie, Wang, Zhang, Liu, Zhan, Zhao, Li, Li and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tumor-originated exosomal LUCAT1 as a circulating biomarker for LUAD. (A) Transmission electron microscopy images of exosomes. Scale bar: 100 nm. (B) Western blot images of exosomal markers (TSG101, CD63, CD9). (C) Size distribution and concentration of serum exosomes. Heatmap (D), volcano plot (E) and scatter plot (F) showed the differentially expressed serum exosomal lncRNAs from the high-throughput sequencing analysis. (G) Comparison of serum exosomal LUCAT1 expression between LUAD patients and healthy controls detected by qRT-PCR. (H) ROC curves for the determination of the diagnostic performance of serum exosomal LUCAT1. (I) Comparison of the expression level of LUCAT1 before and after RNase A treatment. p values were calculated using two-sided paired t-test (*p < 0.05; **p < 0.01; ***p < 0.001).