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In vivo efficacy assay of 4 ADCs on the NCI-N87 xenograft mice model. (A) Tumor volume curve. Red arrows indicate the time-points of ADC administration. Two-tailed t test was used to assess statistical significance between treatment and control groups. ∗∗∗∗P < 0.0001, comparing all ADCs with vehicle; ▹▹▹▹P < 0.0001, comparing gsADC-2 with Cys-conjugated ADC (n = 5 per group). Data = mean ± SEM. (B) Body weight curve. (C) Tumor images after dissection.
