Skip to main content
. 2021 Nov 12;12(5):2592–2608. doi: 10.1016/j.apsb.2021.11.006

Figure 1.

Figure 1

Design, characterization, and principle of the pH-responsive self-assembly. (A) Docking and scoring interaction of target compounds with PAD4 protein. (B) Design of the pH-responsive self-assembly molecules. (C) TEM and SEM images of ZD-B at pH 7.4. Scale bar = 0.2 and 5.0 μm. (D) TEM and SEM images of ZD-B at pH 6.5. Scale bar = 200 nm and 1.0 μm. (E) TEM and SEM images of ZD-E-1 at pH 7.4. Scale bar = 50 and 500 nm. (F) TEM and SEM images of ZD-E-1 at pH 6.5. Scale bar = 200 and 500 nm. (G) Size and (H) zeta potentials of ZD-B and ZD-E-1 at different pH within 6 days (assayed on Days 0, 2, 4, and 6). (I‒J) Critical aggregation concentration (CAC) of ZD-E-1 at pH 7.4 and pH 6.5. (K) Drug release curve of ZD-E-1 at pH 7.4 and 6.5. Data are presented as mean ± SD (n = 3).