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. 2021 Nov 18;12(5):2239–2251. doi: 10.1016/j.apsb.2021.11.017

Figure 5.

Figure 5

Rutin was identified as an active component in DLE and was predicted as a potential IGF1R agonist. (A) The DLE-regulated protein interaction network. DLE affected 148 proteins, shown in red, while 359 interacting proteins searched from String are shown in blue. (B) Illustration of module 7 of the protein interaction network (other modules were presented in Fig. S6). Module 7 was involved in the insulin receptor binding pathway. (C) RT-qPCR validation of DLE-mediated IGF1R-related genes (n = 3). The data are shown as the mean ± SD. Statistical analyses were conducted using paired Student's t-tests. ∗P < 0.05, ∗∗P < 0.01 vs. the DMSO-treated group, ns means not significant. (D) Molecular docking results of rutin and IGF1R using the LibDock algorithm. IGF1R, insulin growth factor 1 receptor.