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Schematic representation and crystal structures of ERK1 (PDB ID: 2ZOQ), ERK2 (PDB ID: 1ERK) and ERK5 (PDB ID: 4IC8). All MAPKs contain the Ser/Thr kinase domain between the N-terminal and C-terminal regions. Different additional domains are also present in some MAPKs, including a proline-rich domain 1 (PR1), proline-rich domain 2 (PR2) and nuclear localization sequence (NLS).
