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. 2022 Jan 4;12(5):2171–2192. doi: 10.1016/j.apsb.2021.12.022

Figure 5.

Figure 5

(A) Discovery of compound 23 from the lead compound 19 to improve its potency and affinity to ERK1/2. (B) Crystal structure of 19 bound to ERK2 (PDB ID: 2OJG). (C) Binding mode of compound 21 in complex with ERK2 (PDB ID: 2OJJ).