Table 2.

ERK1/2 allosteric inhibitors.

Inhibitor	Chemical structure	Activity	Ref.
50		NA	89
51		A549 lung carcinoma cell IC50 = 25 μmol/L	89
52		HeLa cell IC50 = 5.0 μmol/L	90
53		HeLa cell IC50 < 2 μmol/L	90
54		HeLa cell IC50 = 5–10 μmol/L	90
55		HeLa cell IC50 = 25–50 μmol/L	90
56		HeLa cell IC50 = 10–25 μmol/L	90
57		NA	91
58		NA	92
59		NA	92
60		NA	92
61		ERK2 IC50 = 9.9 μmol/L	93
62 (SF-3-029)		AP-1 IC50 = 5–10 μmol/L	94
63 (SF-3-030)		AP-1 IC50 = 5–10 μmol/L	94
64 (DEL-22379)		ERK1/2 dimerization IC50 = 500 nmol/L	95