Figure 5.

Intratumoral injection of T17-MnO₂ displays potent therapeutic effects. Mice were inoculated with Hepa1-6 cells on Day 0. (A–C) On Days 8, 14 and 17, mice were treated with either vehicle control (0.9% NaCl), Mn²⁺ (50 mmol/L), MnO₂ (2 mmol/L), T17 (3 μmol/L), T17 plus Mn²⁺ or T17-MnO₂ by i.t. administration. (A) A schematic diagram of the tumor model. (B) Photographs of Hepa1-6 tumors on Day 20. (C, D) Tumor size and body weight were recorded every other day after receiving treatment (Days 9, 11, 13, 15, 17 and 19). Tumor growth curve is shown. (E) H&E staining of tumors. Data are presented as mean ± SD (n = 5). ∗∗∗∗P < 0.0001.