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The efficacy on XLH in animal treated with FGF23 antibody (FGF23-Ab) or Sclerostin antibody (Scl-Ab).
| Treatment | FGF23-Ab | FGF23-Ab | Scl-Ab |
|---|---|---|---|
| Animal model | Hyp mice (♂) | Hyp mice (♂) | Hyp mice (♂, ♀) |
| Dose | 16 mg/kg, 1/week, 4 times | 35 mg/kg, 3/week, 30 times | 25 mg/kg, 1/week, 4 times |
| Serum phosphate (%) | WT: 49%↑ | N/A | WT: 56%↑ |
| Hyp: 127%↑ | Hyp: 31%↑ | Hyp: 80%↑ | |
| Bone strength | N/A | ↑ | ↑ |
| BV/TV | ↑ | ↑ | ↑ |
| Trabecular thickness (Tb.Th) | N/A | ↑ | ↑ |
| Ref. | 85 | 86 | 84 |
