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. 2022 Feb 11;12(5):2224–2238. doi: 10.1016/j.apsb.2022.02.004

Figure 6.

Figure 6

CYP2E1 antagonist alleviates high-fat diet-induced obesity via PPARα–FGF21–beige axis. (A) Body weight gain. (B) Glucose tolerance test. (C) Insulin tolerance test. (D) Representative hematoxylin and eosin (H&E) staining of liver and subcutaneous white adipose tissue (SWAT) sections from phosphate buffered saline (PBS) and diethyldithiocarbamate (DDC)-treated mice, scale bar = 100 μm. (E) Representative uncoupling protein 1 (UCP1) immunohistochemical staining (right) of subcutaneous white adipose tissue (SWAT) sections from PBS and DDC-treated mice, scale bar = 100 μm. (F, G) mRNA expression of the thermogenesis genes in brown adipose tissue (BAT) and SWAT. (H) Rectal temperature. (I) Hepatic mRNA expression of PPARα target genes. (J) Serum FGF21 concentrations. Data are presented as mean ± SEM, n = 6; ∗P < 0.05; ∗∗P < 0.01 and ∗∗∗P < 0.001 by unpaired two-tailed t test.