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. 2022 Feb 11;12(5):2224–2238. doi: 10.1016/j.apsb.2022.02.004

Figure 7.

Figure 7

Anti-obesity effect of Cyp2e1 inhibition is lost in the absence of liver PPARα. (A) Body weight gain. (B) Subcutaneous adipose tissue (SWAT)/body weight ratio. (C) Epididymal adipose tissue (EWAT)/body weight ratio. (D) Glucose tolerance test. (E) Insulin tolerance test. (F) Rectal temperature. (G) Hepatic mRNA expression of PPARα target genes. (H, I) mRNA expression of the thermogenesis genes in brown adipose tissue (BAT) and SWAT. (J) Serum FGF21 concentration. (K) Representative hematoxylin and eosin (H&E) staining of liver and subcutaneous white adipose tissue (SWAT) sections from phosphate buffered saline (PBS) and diethyldithiocarbamate (DDC)-treated mice, scale bar = 50 μm. (L) Representative uncoupling protein 1 (UCP1) staining of SWAT. (M) Liver triglycerides (TG). (N) Liver total cholesterol (TC). (O) Serum TG. (P) Serum TC. (Q) Serum alanine transaminase (ALT) levels. (R) Serum aspartate transaminase (AST) levels. Data are presented as mean ± SEM, n = 6.