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Proposed CYP2E1–PPARα–FGF21 axis in inducing white adipose browning for reducing obesity. CYP2E1 deficiency, either by gene disruption or chemical inhibition, leads to hepatic PPARα activation that decreases lipid accumulation as well as increasing the expression and secretion of FGF21 from the liver. Secreted FGF21 then circulates to the peripheral subcutaneous white adipose to enhance beiging, which in turn increases the energy expenditure and decreases obesity.
