Table 1.
Parameter | PCL-80 nm | mPEG5k-9%-80 nm | mPEG5k-17%-80 nm | mPEG5k-29%-80 nm | mPEG2k-29%-80 nm | mPEG5k-29%-200 nm |
---|---|---|---|---|---|---|
Particle size (nm) | 81.7 ± 0.9 | 82.5 ± 1.1 | 83.2 ± 1.8 | 86.2 ± 0.6 | 85.3 ± 0.9 | 211.5 ± 2.8 |
PDI | 0.104 ± 0.010 | 0.113 ± 0.008 | 0.115 ± 0.010 | 0.108 ± 0.008 | 0.112 ± 0.008 | 0.102 ± 0.005 |
Zeta-potential (mV) | ‒1.22 ± 0.04 | ‒1.25 ± 0.11 | ‒1.27 ± 0.09 | ‒1.33 ± 0.10 | ‒1.24 ± 0.04 | ‒1.28 ± 0.07 |
Entrapment efficiency (%) | 22.43 ± 0.82 | 20.74 ± 0.5 | 21.49 ± 1.59 | 22.97 ± 1.39 | 21.69 ± 1.55 | 36.47 ± 1.56 |
Drug loading (%) | 0.87 ± 0.03 | 0.79 ± 0.01 | 0.73 ± 0.03 | 0.62 ± 0.03 | 0.62 ± 0.02 | 0.62 ± 0.02 |
Fluorescence intensity (×109) | 5.31 ± 0.15 | 5.17 ± 0.09 | 5.58 ± 0.22 | 5.10 ± 0.18 | 5.29 ± 0.13 | 5.31 ± 0.18 |
Data are presented as mean ± SD (n = 3).