Table 3.
Pharmacokinetic parameters of DOX after intravenous injection of a single dose of DOX-loaded mPEG-PCL nanoparticles by fitting to a two-compartmental model in ratsa.
| Parameter | PCL-80 nm | mPEG5k-9%-80 nm | mPEG5k-17%-80 nm | mPEG5k-29%-80 nm | mPEG2k-29%-80 nm | mPEG5k-29%-200 nm | DOX |
|---|---|---|---|---|---|---|---|
| t1/2α (h) | 0.02 ± 0.01 | 0.09 ± 0.02 | 0.09 ± 0.03 | 0.11 ± 0.02 | 0.09 ± 0.04 | 0.02 ± 0.00 | 0.05 ± 0.01 |
| t1/2β (h) | 0.17 ± 0.01 | 0.73 ± 0.22 | 0.69 ± 0.31 | 0.9 ± 0.08 | 1.12 ± 1.02 | 0.53 ± 0.05 | 46.47 ± 39.56 |
| K10 (L/h) | 8.76 ± 5.79 | 3.03 ± 0.26 | 2.42 ± 0.13 | 1.38 ± 0.06 | 3.12 ± 0.51 | 2.63 ± 0.34 | 7.50 ± 0.70 |
| K12 (L/h) | 40.88 ± 49.48 | 3.96 ± 1.06 | 3.48 ± 1.07 | 2.53 ± 0.54 | 4.78 ± 2.76 | 15.96 ± 3.54 | 5.56 ± 2.26 |
| K21 (L/h) | 25.24 ± 7.80 | 2.42 ± 1.06 | 3.53 ± 2.22 | 3.25 ± 0.94 | 2.8 ± 2.23 | 13.45 ± 1.43 | 0.46 ± 0.70 |
| AUC0‒t (%∗h) | 31.4 ± 0.45 | 50.34 ± 1.15 | 76.27 ± 1.48 | 102.43 ± 4.13 | 55.78 ± 1.47 | 39.14 ± 2.13 | 3.71 ± 0.21 |
| MRT (h) | 8.02 ± 0.24 | 11.57 ± 0.12 | 12.66 ± 0.41 | 8.72 ± 0.14 | 13.76 ± 0.28 | 4.78 ± 0.10 | 0.45 ± 0.00 |
a
Data are presented as mean ± SD (n = 3).