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GWASs for CFTR F508del heterozygosity versus homozygosity
(Top) The baseline model adjusted for site and relatedness. (Bottom) The PC-adjusted model. Association signals are measured as -log10(p values). Plot is truncated at p = 1 × 10-10, as the peak at CFTR on chr7 reaches p < 1 × 10-300 under both models. The genome-wide significance level, p < 5 × 10-8, is indicated by the horizontal line.
