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. 2022 May 13;25(6):104405. doi: 10.1016/j.isci.2022.104405

Figure 4.

Figure 4

Construction of tissue-engineered NP by NPMSCs and the chitosan composite fibrin gel scaffold

(A) Representative images of the fibrin gel scaffolds at various concentrations were acquired by electron microscopy.

(B) Representative electron micrographs of tissue-engineered NP constructed by NPMSCs and the chitosan composite fibrin gel scaffold. The growth of NPMSCs was better than that in the other groups when the concentration of the chitosan composite fibrin gel scaffold was 50 mg/mL. The white arrows indicate cells attached to the scaffold.

(C) Representative histological images of tissue-engineered NP were obtained. Alone used BMP-2 can promote the differentiation of cartilage-like cells, also cause its osteogenic differentiation. Under the combined action of PMS, osteogenic differentiation was obviously inhibited. Magnification: 40× (left), 200 × (right). Scale bars: 50 and 20 μm for low and high magnification, respectively. Determination of sustained release performance of scaffolds see also Figure S2.