Skip to main content
. Author manuscript; available in PMC: 2022 May 27.
Published in final edited form as: Nat Genet. 2016 May 2;48(6):634–639. doi: 10.1038/ng.3561

Figure 1.

Figure 1

Relationship between the effect of sequence variants on non-HDL cholesterol and their effect on risk of coronary artery disease, (a) Effect on CAD risk of 100 known common (minor allele frequency (MAF) >5%) lipid-associated variants11,29,30 that associate with non-HDL cholesterol in Iceland (P < 0.05). (b) Effect on CAD of the 27 rare and low-frequency lipid-associated variants identified in this study. Previously published variants are colored blue, and new variants are colored red. In both plots, the effect on non-HDL cholesterol (n = 119,146) is given in mmol/L, and the effect on CAD risk (n = 33,090 cases and 236,254 controls) is represented by the odds ratio (OR). Bars represent 95% confidence intervals for the effect on non-HDL cholesterol and risk of CAD. The black line is the line best fitting the common variant, and the gray line is the line best fitting the CAD odds ratio on the log scale transformed back to the original scale.