Table 2.

Effect of variants that associate with coronary artery disease on age at diagnosis and lifespan

		CAD (n = 33,090 cases, 236,254 controls)		Age at diagnosis of CAD (n = 33,090)		Lifespan (n = 61,060)
Variant	A2 (%)	OR	P	β	P	β	P
PCSK9 (rs11591147)	1.17	0.73	3.1 × 10−6	2.44	0.0005	0.78	0.081
APOA1 (p.Val43Leu)	0.70	0.74	0.0004	2.00	0.027	1.40	0.015
ANGPTL4 (rs116843064)	2.39	0.80	3.4 × 10−6	0.97	0.047	0.28	0.38
LDLR (rs200238879)	0.056	2.76	0.0003	−8.83	0.0001	−6.54	0.0010
LDLR (rs72658867)	2.22	0.77	1.0 × 10−7	1.18	0.018	0.54	0.09

All effects (odds ratio and β) are given with respect to allele A2 (allele information appears in Table 1). Effects (β) for association with age at diagnosis of CAD and lifespan are in years. Lifespan (number of years lived) is the mean age at death of individuals born after 1890 who lived to be at least 50 years old. The APOA1 variant encoding p.Val43Leu is located on chromosome 11 at 116,837,074 bp in Build 38 of the human reference sequence. CAD, coronary artery disease; OR, odds ratio; A2 (%), frequency of allele A2.