Table 3.

Association of genetic risk scores with coronary artery disease

			GRS 1		GRS 2		GRS-all
Outcome	Predictor	Covariate	β	P	β	P	β	P
CAD	Non-HDL-C GRS	–	0.44	7.6 × 10−14	0.27	4.6 × 10−19	0.28	2.7 × 10−28
		HDL-C GRS, TG GRS	0.45	5.8 × 10−11	0.23	2.4 × 10−11	0.26	4.4 × 10−18
		LDL-C GRS	0.56	3.2 × 10−4	0.36	3.8 × 10−5	0.41	5.5 × 10−8
CAD	LDL GRS	–	0.40	2.8 × 10−11	0.24	1.3 × 10−15	0.25	1.4 × 10−22
		HDL-C GRS, TG GRS	0.36	6.7 × 10−9	0.21	1.6 × 10−11	0.22	7.4 × 10−17
		Non-HDL-C GRS	−0.13	0.40	−0.10	0.25	−0.13	0.075
CAD	HDL-C GRS	–	−0.17	0.0001	−0.09	0.0006	−0.09	9.0 × 10−6
		Non-HDL-C GRS, TG GRS	−0.08	0.13	−0.016	0.57	−0.017	0.44
		LDL-C GRS, TG GRS	−0.09	0.08	−0.020	0.48	−0.022	0.34
CAD	TG GRS	–	0.22	0.0007	0.21	6.4 × 10−10	0.20	4.9 × 10−12
		Non-HDL-C GRS, HDL-C GRS	−0.10	0.19	0.07	0.11	0.042	0.24
		LDL-C GRS, HDL-C GRS	0.06	0.43	0.14	0.0002	0.13	7.5 × 10−5

GRSs were calculated using data from 104,131 individuals (15,575 CAD cases and 88,556 controls). GRS 1 was based on 27 rare and low-frequency lipid-associated variants identified in this study. GRS 2 was based on 185 known lipid-associated variants. GRS-all is the combination of GRS 1 and GRS 2. The effect (β) for CAD is the logarithm of the odds ratio for CAD per 1 s.d. of the predictor. CAD, coronary artery disease; GRS, genetic risk score; non-HDL-C, non-HDL cholesterol; LDL-C, LDL cholesterol; HDL-C, HDL cholesterol; TG, triglycerides.