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. 2022 Apr 27;13:841766. doi: 10.3389/fphar.2022.841766

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Copyright © 2022 Ruiz de Martín Esteban, Benito-Cuesta, Terradillos, Martínez-Relimpio, Arnanz, Ruiz-Pérez, Korn, Raposo, Sarott, Westphal, Elezgarai, Carreira, Hillard, Grether, Grandes, Grande and Romero.

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Cannabinoid CB₂ receptors modulate amyloid dynamics in vivo. No changes were evident after treatment in APP (A), C83 (B) or BACE1 (C), as measured by western blot. Soluble amyloid levels (D) remained also unaltered, while those of insoluble amyloid (E) were significantly increased by the exposure to the CB₂ agonist and decreased in 5xFAD/CB₂ ^-/- mice. Two-way ANOVA followed by Tukey’s post-hoc test. *<p0.05; ****<p0.0001. N = 4-6 mice per group. Data represent mean ± SEM.