(A) Detection of target analyte using a smart thermometer. Reprinted (adapted) with permission from J. Zhang, H. Xing and Y. Lu, Translating molecular detections into a simple temperature test using a target-responsive smart thermometer, Chem. Sci., 2018, 9, 3906–3910. Copyright 2018, The Royal Society of Chemistry.301 (B) ANDalyze Portable Fluorescence Reader and disposable sensors. Copyright permission granted by ANDalyze.