Skip to main content
. Author manuscript; available in PMC: 2022 May 27.
Published in final edited form as: Chem Soc Rev. 2021 Jul 6;50(16):8954–8994. doi: 10.1039/d1cs00240f

Fig. 9.

Fig. 9

DNAzyme sensors for metal-ion imaging in living cells. (A) The first intracellular DNAzyme based sensor for uranyl ion detection in living cells using 39E immobilized onto gold nanoparticles. Reprinted (adapted) with permission from P. Wu, K. Hwang, T. Lan and Y. Lu, A DNAzyme-Gold Nanoparticle Probe for Uranyl Ion in Living Cells, J. Am. Chem. Soc., 2013, 135, 5254–5257. Copyright 2013 American Chemical Society.214 (B) A DNAzyme sensor for metal-ion imaging in living cells with blockage of the 2′-OH of the scissile ribonucleotide with a light-sensitive nitrobenzyl group. Reprinted (adapted) with permission from K. Hwang, P. Wu, T. Kim, L. Lei, S. Tian, Y. Wang and Y. Lu, Photocaged DNAzymes as a General Method for Sensing Metal Ions in Living Cells, Angew. Chem., Int. Ed., 2014, 53, 13798–13802. Copyright 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.217 (C) Zn2+ sensing in vivo using photocaged Zn2+-selective DNAzyme conjugated on lanthanide-doped upconversion nanoparticles (UCNPs). Reprinted (adapted) with permission from Z. Yang, K. Y. Loh, Y.-T. Chu, R. Feng, N. S. R. Satyavolu, M. Xiong, S. M. Nakamata Huynh, K. Hwang, L. Li, H. Xing, X. Zhang, Y. R. Chemla, M. Gruebele and Y. Lu, Optical Control of Metal Ion Probes in Cells and Zebrafish Using Highly Selective DNAzymes Conjugated to Upconversion Nanoparticles, J. Am. Chem. Soc., 2018, 140, 17656–17665. Copyright 2018 American Chemical Society.219