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Inhibition of GPCR or ITAM signaling in mouse platelets does not impair thrombin generation. Thrombin generation was measured by calibrated automated thrombography in PRP (Control) and platelet-poor plasma (PPP) (A), and in plasma from mice treated with high DAPT (B) or ibrutinib (C). Curves show mean ± standard error of the mean for all mice for each condition; the number of mice studied is indicated in Table 1.
