Table 1.
Demographic characteristics and laboratory measurements by tertile of monocyte count and monocyte/lymphocyte ratio
| Characteristics | Overall cohort (N=3391) | Monocyte Count | Monocyte/Lymphocyte Ratio | ||||
|---|---|---|---|---|---|---|---|
| Tertile 1, <400/mm3 (N=1003) | Tertile 2, ≥400 and <523/mm3 (N=1225) | Tertile 3, ≥523/mm3 (N=1133) | Tertile 1, <0.23 (N=1107) | Tertile 2, ≥0.23 and <0.33 (N=1068) | Tertile 3, ≥0.33 (N=1216) | ||
| Monocyte count, mm3, median (IQR) | 470 (365–600) | 300 (260–346) | 455 (400–500) | 640 (600–750) | — | — | — |
| MLR, median (IQR) | 0.28 (0.21–0.38) | — | — | — | 0.18 (0.15–0.2) | 0.27 (0.25–0.3) | 0.42 (0.36–0.5) |
| Age, yr, mean±SD | 58±11 | 58±11 | 58±11 | 59±11 | 57±11 | 58±11 | 60±11 |
| Women, n (%) | 1553 (46) | 589 (59) | 554 (44) | 410 (36) | 704 (64) | 473 (44) | 376 (31) |
| Race, n (%) | |||||||
| White | 1686 (50) | 447 (45) | 642 (51) | 597 (53) | 413 (37) | 528 (49) | 745 (61) |
| Black | 1530 (45) | 493 (49) | 551 (44) | 486 (43) | 673 (58) | 471 (44) | 422 (35) |
| Other | 175 (5) | 63 (6) | 62 (5) | 50 (4) | 57 (5) | 69 (7) | 49 (4) |
| BMI, kg/m2, mean±SD | 32.1±8 | 31.2±7.9 | 32.1±7.7 | 33±8.2 | 32.4±8.3 | 32.1±7.8 | 31.9±7.7 |
| Current smoking, n (%) | 456 (13) | 118 (12) | 163 (13) | 175 (15) | 195 (18) | 127 (12) | 134 (11) |
| CVD, n (%) | 1152 (34) | 278 (28) | 414 (33) | 460 (41) | 317 (29) | 364 (34) | 471 (39) |
| Diabetes, n (%) | 1573 (46) | 410 (41) | 592 (47) | 571 (50) | 485 (44) | 491 (46) | 597 (49) |
| # Antihypertensives, mean±SD | 2.6±1.5 | 2.4±1.6 | 2.6±1.5 | 2.9±1.5 | 2.4±1.5 | 2.6±1.5 | 2.8±1.5 |
| Statin use, n (%) | 1870 (55) | 495 (49) | 713 (57) | 662 (58) | 576 (52) | 588 (55) | 706 (58) |
| SBP, mm Hg, mean±SD | 127±22 | 126±22 | 128±21 | 128±22 | 126±21 | 128±22 | 129±22 |
| Cholesterol, mg/dl, mean±SD | 183±44 | 188±45 | 183±46 | 178±41 | 190±47 | 182±43 | 176±41 |
| HDL cholesterol, mean±SD | 48±16 | 52±17 | 47±14 | 46±14 | 50±16 | 48±15 | 47±15 |
| eGFR, ml/min per 1.73 m2, mean±SD | 45±15 | 46±16 | 45±15 | 43±14 | 47±16 | 45±15 | 43±14 |
| Urinary albumin, g/24 h, median (IQR) | 0.06 (0.01–0.49) | 0.03 (0.01–0.37) | 0.06 (0.01–0.51) | 0.08 (0.01–0.55) | 0.04 (0.01–0.41) | 0.06 (0.01–0.49) | 0.08 (0.01–0.54) |
| hs-CRP, mg/L, median (IQR) | 2.57 (1.05–6.52) | 1.87 (0.82–4.87) | 2.42 (1.07–5.81) | 3.58 (1.35–8.5) | 2.5 (0.96–6.61) | 2.22 (0.96–5.71) | 3.01 (1.22–7.27) |
BMI, body mass index; CVD, cardiovascular disease; hs-CRP, high-sensitivity C-reactive protein; IQR, interquartile range; MLR, monocyte/lymphocyte ratio; SBP, systolic blood pressure.