Table 2.
Associations of monocyte count with cardiovascular disease, cardiovascular disease death, and all-cause death
| Tertile 1, <400/mm3 (N=1003) | Tertile 2, ≥400 and <523/mm3 (N=1225) | Tertile 3, ≥523/mm3 (N=1133) | Per Doubling of Monocyte Count | |
|---|---|---|---|---|
| CVD | ||||
| Unadjusted | Ref. | 1.25 (1.1 to 1.42) | 1.77 (1.57 to 2.01) | 1.52 (1.39 to 1.65) |
| Model 1 | Ref. | 1.21 (1.06 to 1.38) | 1.64 (1.44 to 1.86) | 1.42 (1.3 to 1.54) |
| Model 2 | Ref. | 1.15 (1.01 to 1.32) | 1.43 (1.25 to 1.63) | 1.28 (1.17 to 1.4) |
| Model 3 | Ref. | 1.13 (0.99 to 1.29) | 1.37 (1.2 to 1.56) | 1.25 (1.14 to 1.36) |
| Model 4 | Ref. | 1.11 (0.97 to 1.27) | 1.31 (1.14 to 1.49) | 1.2 (1.1 to 1.31) |
| CVD death | ||||
| Unadjusted | Ref. | 1.38 (1.06 to 1.79) | 1.87 (1.45 to 2.41) | 1.59 (1.34 to 1.89) |
| Model 1 | Ref. | 1.23 (0.94 to 1.61) | 1.61 (1.23 to 2.09) | 1.45 (1.21 to 1.72) |
| Model 2 | Ref. | 1.13 (0.87 to 1.48) | 1.33 (1.02 to 1.73) | 1.27 (1.07 to 1.51) |
| Model 3 | Ref. | 1.13 (0.86 to 1.47) | 1.26 (0.97 to 1.64) | 1.22 (1.03 to 1.46) |
| Model 4 | Ref. | 1.11 (0.85 to 1.45) | 1.2 (0.92 to 1.58) | 1.18 (0.99 to 1.41) |
| All-cause death | ||||
| Unadjusted | Ref. | 1.32 (1.13 to 1.53) | 1.89 (1.63 to 2.19) | 1.55 (1.41 to 1.71) |
| Model 1 | Ref. | 1.2 (1.03 to 1.41) | 1.68 (1.45 to 1.96) | 1.43 (1.29 to 1.58) |
| Model 2 | Ref. | 1.14 (0.98 to 1.33) | 1.47 (1.26 to 1.71) | 1.29 (1.16 to 1.42) |
| Model 3 | Ref. | 1.12 (0.96 to 1.31) | 1.38 (1.18 to 1.61) | 1.23 (1.11 to 1.36) |
| Model 4 | Ref. | 1.1 (0.94 to 1.29) | 1.3 (1.11 to 1.52) | 1.17 (1.06 to 1.3) |
Data are shown as hazard ratios (95% CI). Model 1: Unadjusted+demographics (age, sex, race, and clinic site). Model 2: Model 1+traditional CVD risk factors (systolic blood pressure, number of antihypertensives, total cholesterol, HDL cholesterol, statin use, smoking status, prevalent CVD, and prevalent diabetes). Model 3: Model 2+markers of kidney disease (eGFR and urinary albumin). Model 4: Model 3+hs-CRP. CI, confidence interval; CVD, cardiovascular disease; Ref., reference; hs-CRP, high-sensitivity C-reactive protein.