Table 3.

Associations of monocyte/lymphocyte ratio with cardiovascular disease event, cardiovascular disease death, and all-cause death

	Tertile 1, <0.23 (N=1107)	Tertile 2, ≥0.23 and <0.33 (N=1068)	Tertile 3, ≥0.33 (N=1216)	Per Doubling of MLR
CVD
Unadjusted	Ref.	1.18 (1.03 to 1.34)	1.66 (1.48 to 1.87)	1.39 (1.29 to 1.48)
Model 1	Ref.	1.14 (1 to 1.31)	1.6 (1.41 to 1.82)	1.34 (1.25 to 1.44)
Model 2	Ref.	1.11 (0.97 to 1.27)	1.54 (1.35 to 1.75)	1.32 (1.23 to 1.43)
Model 3	Ref.	1.1 (0.96 to 1.25)	1.46 (1.28 to 1.67)	1.29 (1.19 to 1.39)
Model 4	Ref.	1.09 (0.95 to 1.24)	1.41 (1.23 to 1.61)	1.26 (1.16 to 1.36)
CVD death
Unadjusted	Ref.	1.18 (0.9 to 1.54)	1.97 (1.55 to 2.5)	1.56 (1.37 to 1.78)
Model 1	Ref.	1.04 (0.79 to 1.38)	1.67 (1.29 to 2.16)	1.42 (1.23 to 1.63)
Model 2	Ref.	1.03 (0.78 to 1.37)	1.55 (1.19 to 2.02)	1.36 (1.18 to 1.58)
Model 3	Ref.	1.01 (0.76 to 1.33)	1.43 (1.09 to 1.86)	1.3 (1.12 to 1.51)
Model 4	Ref.	1 (0.76 to 1.32)	1.38 (1.06 to 1.81)	1.27 (1.1 to 1.48)
All-cause death
Unadjusted	Ref.	1.23 (1.06 to 1.43)	1.77 (1.54 to 2.03)	1.43 (1.32 to 1.54)
Model 1	Ref.	1.14 (0.98 to 1.33)	1.58 (1.36 to 1.84)	1.33 (1.22 to 1.45)
Model 2	Ref.	1.14 (0.97 to 1.33)	1.52 (1.3 to 1.77)	1.3 (1.19 to 1.41)
Model 3	Ref.	1.1 (0.94 to 1.28)	1.38 (1.18 to 1.61)	1.23 (1.13 to 1.34)
Model 4	Ref.	1.08 (0.93 to 1.27)	1.31 (1.12 to 1.53)	1.18 (1.09 to 1.29)

Data are shown as hazard ratios (95% CI). Model 1: Unadjusted+demographics (age, sex, race, and clinic site). Model 2: Model 1+traditional CVD risk factors (systolic blood pressure, number of antihypertensives, total cholesterol, HDL cholesterol, statin use, smoking status, prevalent CVD, and prevalent diabetes). Model 3: Model 2+markers of kidney disease (eGFR and urinary albumin). Model 4: Model 3+hs-CRP. CVD, cardiovascular disease; Ref., reference; MLR, monocyte/lymphocyte ratio.