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. 2022 May 17;144(20):8945–8950. doi: 10.1021/jacs.2c03925

Figure 4.

Figure 4

(A) Spike194–203 properties. (B) Spike194–203 amyloidogenicity monitored by ThT kinetics, Congo red birefringence, and TEM. (C) Thrombin activated fibrin formation and plasminogen/tPA-induced fibrinolysis in the absence and presence of seven-peptide-mix amyloid fibrils (Table 1, Figure S3). (D) Turbidity difference after fibrin formation and fibrinolysis in the absence and presence of Spike192 fibrils and Spike194–203 fibrils (n = 10–12 replicates of each reaction, corrected for background scatter).