Table 1.

Osteosarcoma (OS) age standardized incidence rates (ASR) per million and number of cases (N) by time period and age category and the average annual percent change (AAPC) in incidence over 1988–2012 from the Cancer Incidence in Five Continents (CI5) data

		Age Standardized Incidence Rates1 (N)
	Age group	1988–1992	1993–1997	1998–2002	2003–2007	2008–2012	AAPC (95% CI)2,3
Northern Africa	0–9 yrs	-(2)	2.7(6)	1.8(10)	1.3(12)	-(3)	−3.2 (−9.6, 3.6)
	10–19 yrs	-(4)	11.9(29)	7.2(40)	8.2(81)	9.4(24)	−0.3 (−7.2, 7.1)
	20–29 yrs	-(3)	7.7(18)	5.0(23)	3.5(31)	4.1(11)	−4.0 (−10.7, 3.1)
	30–59 yrs	-(2)	3.2(10)	1.9(13)	1.9(29)	3.4(13)	0.4 (−8.4, 10.1)
	60–79 yrs	-(0)	10.4(8)	-(3)	0.9(4)	-(2)	-
	0–79 yrs	2.5(11)	5.9(71)	3.3(89)	3.1(157)	4.1(53)	−2.1 (−9.8, 6.3)
Sub-Saharan Africa	0–9 yrs	-(3)	-(1)	1.3(5)	1.1(7)	0.9(8)	0.7 (−8.4, 10.7)
	10–19 yrs	3.8(11)	7.8(33)	8.7(35)	6.2(40)	6.8(53)	0.2 (−5.3, 6.0)
	20–29 yrs	4.0(12)	2.8(11)	2.4(10)	3.2(19)	3.5(33)	0.1 (−3.6, 3.9)
	30–59 yrs	-(4)	-(4)	2.3(7)	2.8(16)	4.7(37)	8.8 (3.0, 14.9)
	60–79 yrs	-(3)	-(1)	-(3)	5.9(5)	4.9(6)	-
	0–79 yrs	2.5(33)	2.3(50)	3.7(60)	3.5(87)	4.2(137)	3.1 (0.5, 5.8)
Caribbean	0–9 yrs	-(0)	-(4)	-(1)	1.7(7)	1.6(5)	-
	10–19 yrs	-(0)	5.0(10)	7.2(6)	6.1(27)	7.3(26)	2.2 (−2.3, 6.8)
	20–29 yrs	-(0)	-(4)	-(2)	2.9(12)	2.1(7)	-
	30–59 yrs	-(0)	-(2)	-(2)	1.6(18)	1.4(13)	-
	60–79 yrs	-(0)	4.4(6)	-(0)	2.6(10)	1.7(6)	−5.4 (−16.9, 7.6)
	0–79 yrs	-(0)	2.2(26)	2.3(11)	2.7(74)	2.6(57)	1.1 (−2.2, 4.6)
Central America	0–9 yrs	-(4)	-(3)	1.2(5)	-(2)	-(3)	-
	10–19 yrs	5.2(16)	9.7(14)	8.5(35)	5.6(24)	7.3(25)	0.2 (−5.8, 6.5)
	20–29 yrs	2.1(6)	-(1)	2.9(10)	3.1(12)	2.4(8)	1.4 (−4.8, 7.9)
	30–59 yrs	-(4)	-(1)	-(4)	0.8(6)	1.6(11)	-
	60–79 yrs	-(0)	-(0)	-(1)	-(1)	-(2)	-
	0–79 yrs	1.8(30)	2.4(19)	2.5(55)	1.9(45)	2.6(49)	1.1 (−2.3, 4.6)
South America	0–9 yrs	1.4(12)	1.6(9)	2.5(39)	1.6(39)	1.5(37)	−1.0 (−7.6, 6.0)
	10–19 yrs	8.9(80)	8.6(51)	13.5(228)	11.7(307)	9.2(243)	−0.3 (−5.3, 5.0)
	20–29 yrs	4.3(37)	3.4(20)	5.9(101)	4.3(112)	3.2(83)	−1.8 (−7.7, 4.4)
	30–59 yrs	3.1(40)	1.7(18)	3.0(96)	1.8(94)	1.6(90)	−3.4 (−8.2, 1.7)
	60–79 yrs	5.2(16)	5.6(14)	2.1(17)	3.3(42)	3.3(48)	−2.2 (−7.9, 3.9)
	0–79 yrs	4.2(185)	3.6(112)	5.1(481)	4.1(594)	3.3(501)	0.3 (−0.5, 1.0)
North America	0–9 yrs	1.5(53)	1.7(63)	1.5(107)	1.6(125)	1.7(125)	0.6 (−0.6, 1.8)
	10–19 yrs	7.4(251)	7.9(296)	8.2(575)	7.9(637)	8.1(626)	0.3 (−0.4, 0.9)
	20–29 yrs	2.3(92)	3.0(116)	3.1(211)	3.0(241)	3.0(240)	0.8 (−1.1, 2.8)
	30–59 yrs	1.5(149)	1.8(203)	1.8(362)	1.7(426)	1.7(399)	0.1 (−1.1, 1.4)
	60–79 yrs	3.6(120)	3.6(133)	3.2(194)	3.1(235)	3.0(243)	−0.9 (−1.5, −0.3)
	0–79 yrs	2.9(665)	3.2(811)	3.2(1449)	3.1(1664)	3.2(1633)	0.3 (−0.5, 1.0)
Eastern Asia	0–9 yrs	0.7(16)	1.0(34)	1.6(71)	1.5(79)	1.7(105)	3.3 (−0.5, 7.3)
	10–19 yrs	5.8(128)	5.7(240)	7.5(372)	8.3(518)	7.3(579)	1.4 (−1.3, 4.2)
	20–29 yrs	1.3(33)	2.1(102)	2.5(147)	2.0(150)	2.4(247)	1.3 (−2.6, 5.4)
	30–59 yrs	1.1(83)	1.3(171)	1.6(250)	1.7(395)	2.0(650)	2.6 (2.0, 3.1)
	60–79 yrs	3.2(70)	3.2(120)	2.4(114)	2.9(208)	3.6(415)	1.0 (−2.1, 4.3)
	0–79 yrs	2.1(330)	2.4(667)	2.8(954)	3.0(1350)	3.1(1996)	1.8 (0.6, 2.9)
South-eastern Asia	0–9 yrs	-(4)	1.3(33)	1.6(23)	1.5(38)	1.3(36)	1.4 (−5.4, 8.7)
	10–19 yrs	6.6(70)	8.0(208)	11.0(145)	10.6(267)	9.2(267)	1.4 (−2.1, 5.0)
	20–29 yrs	2.3(26)	3.4(97)	4.0(54)	3.4(93)	2.6(93)	−0.6 (−4.9, 3.8)
	30–59 yrs	1.3(22)	1.7(82)	2.2(60)	2.3(131)	2.2(158)	2.1 (−0.1, 4.4)
	60–79 yrs	2.5(8)	2.8(26)	3.3(19)	4.7(50)	4.4(61)	3.2 (0.4, 6.1)
	0–79 yrs	2.4(130)	3.1(446)	4.0(301)	4.0(579)	3.6(615)	1.4 (−1.9, 4.8)
Southern Asia	0–9 yrs	0.7(15)	0.6(23)	0.9(31)	0.7(28)	0.5(19)	−1.3 (−6.4, 4.1)
	10–19 yrs	6.1(117)	6.1(219)	6.2(222)	6.7(324)	4.9(220)	−0.6 (−3.5, 2.3)
	20–29 yrs	3.0(60)	3.5(222)	2.6(96)	3.0(149)	2.0(101)	−2.0 (−5.7, 1.8)
	30–59 yrs	1.0(30)	1.3(324)	2.9(168)	1.5(115)	1.4(128)	−0.5 (−11.3, 11.7)
	60–79 yrs	2.5(12)	3.2(220)	6.7(72)	2.5(40)	1.8(36)	−3.2 (−10.3, 4.4)
	0–79 yrs	2.3(234)	2.6(1102)	3.5(589)	2.6(656)	2.0(504)	−1.1 (−2.9, 0.7)
Western Asia	0–9 yrs	0.9(6)	1.1(12)	0.8(14)	1.4(27)	1.1(34)	0.9 (−4.3, 6.4)
	10–19 yrs	7.0(40)	6.9(66)	7.1(116)	7.5(136)	6.6(200)	−0.2 (−1.6, 1.1)
	20–29 yrs	4.2(21)	3.6(29)	2.0(31)	3.8(70)	2.6(81)	−1.5 (−7.5, 5.0)
	30–59 yrs	1.8(18)	2.1(32)	1.8(55)	1.6(58)	1.2(81)	−2.8 (−5.2, −0.3)
	60–79 yrs	2.9(10)	2.2(8)	3.1(24)	2.0(19)	1.8(27)	−2.5 (−6.7, 1.8)
	0–79 yrs	3.1(95)	3.0(147)	2.7(240)	3.0(310)	2.4(423)	−1.1 (−2.9, 0.7)
Eastern Europe	0–9 yrs	0.7(18)	0.5(12)	1.0(24)	0.8(32)	1.1(48)	2.3 (−2.7, 7.5)
	10–19 yrs	4.8(120)	4.1(114)	5.9(177)	5.4(334)	6.1(322)	1.4 (−0.8, 3.7)
	20–29 yrs	1.8(39)	1.6(40)	1.8(60)	2.0(144)	2.1(158)	1.2 (−0.1, 2.5)
	30–59 yrs	1.1(70)	0.9(68)	1.2(106)	1.4(274)	1.5(320)	1.9 (0.9, 3.7)
	60–79 yrs	2.9(66)	1.5(42)	2.6(96)	4.0(322)	3.4(285)	2.1 (−4.1, 8.6)
	0–79 yrs	2.0(313)	1.6(276)	2.3(463)	2.3(1106)	2.5(1133)	1.6 (−0.5, 3.8)
Northern Europe	0–9 yrs	1.0(40)	1.3(81)	1.3(70)	1.1(61)	1.5(74)	1.1 (−2.2, 4.5)
	10–19 yrs	6.2(262)	7.0(400)	7.2(426)	6.5(406)	7.2(368)	0.2 (−1.0, 1.5)
	20–29 yrs	2.7(132)	2.6(166)	2.6(148)	2.4(146)	2.3(129)	−0.9 (−1.2, −0.5)
	30–59 yrs	1.1(142)	1.2(221)	1.4(271)	1.3(268)	1.5(259)	1.2 (−0.2, 2.5)
	60–79 yrs	3.1(148)	2.3(171)	2.2(166)	2.3(189)	2.3(168)	−0.6 (−2.0, 0.9)
	0–79 yrs	2.7(724)	2.6(1039)	2.7(1081)	2.5(1070)	2.7(998)	0.4 (−0.7, 1.4)
Southern Europe	0–9 yrs	1.4(17)	1.2(17)	1.3(26)	1.3(28)	1.8(37)	1.7 (−1.3, 4.7)
	10–19 yrs	5.2(81)	6.2(103)	7.0(165)	7.3(164)	7.9(162)	1.9 (1.0, 2.9)
	20–29 yrs	2.2(36)	2.1(42)	3.4(102)	2.6(73)	1.8(42)	−0.5 (−7.7, 7.2)
	30–59 yrs	1.2(55)	1.3(75)	2.1(85)	1.8(172)	1.5(135)	0.6 (−5.1, 6.6)
	60–79 yrs	2.3(43)	2.2(56)	4.8(197)	3.1(133)	2.3(95)	−0.4 (−10.3, 10.2)
	0–79 yrs	2.2(232)	2.4(293)	3.3(675)	2.9(570)	2.8(471)	1.0 (−2.5, 4.7)
Western Europe	0–9 yrs	0.8(14)	1.3(25)	1.2(37)	1.1(40)	1.4(75)	1.8 (−1.7, 5.4)
	10–19 yrs	7.3(139)	8.5(154)	8.0(280)	8.9(345)	8.1(476)	0.4 (−1.0, 1.8)
	20–29 yrs	2.4(58)	3.1(69)	2.6(93)	2.9(120)	2.8(180)	0.4 (−1.4, 2.3)
	30–59 yrs	2.0(116)	1.7(107)	1.7(210)	1.5(222)	1.7(383)	−0.6 (−2.1, 1.0)
	60–79 yrs	2.3(52)	2.5(58)	2.7(135)	2.8(175)	2.7(275)	0.7 (−0.2, 1.6)
	0–79 yrs	2.8(379)	3.1(413)	2.9(755)	3.1(902)	3.1(1392)	0.3 (−0.4, 1.0)
Oceania	0–9 yrs	0.6(8)	0.9(14)	1.4(23)	1.2(19)	0.8(14)	1.1 (−6.3, 9.1)
	10–19 yrs	4.4(60)	6.8(105)	7.7(126)	8.8(148)	8.2(143)	2.5 (−0.7, 5.8)
	20–29 yrs	1.2(17)	2.9(49)	3.5(58)	2.1(35)	2.6(49)	0.6 (−7.2, 9.2)
	30–59 yrs	1.5(50)	1.7(71)	1.5(74)	1.6(79)	1.6(85)	0.0 (−0.6, 0.7)
	60–79 yrs	2.5(30)	4.7(74)	3.4(52)	2.5(43)	2.9(58)	−1.6 (−7.6, 4.7)
	0–79 yrs	1.9(165)	2.9(313)	3.1(333)	2.9(324)	2.9(349)	1.2 (−2.1, 4.5)

¹Rates were not calculated for strata with less than 5 cases are denoted by a dash (-).

²Estimates in bold are statistically significant.

³AAPCs were not calculated for categories with < 5 cases for 3 or more time periods, as denoted by a dash (-).