Table 2.
a The MIC results of 43 MDR-MTB isolates. b pDST resistance pattern of pre-XDR and XDR strains (n)
| a | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| INH | RFP | RFB | EMB | Mfx | Ofx | Eto | Pas | Km | Ak | Sm | Cs | |
| CCs (ug/ml) | 0.2 | 1.0 | 0.5 | 5.0 | 0.5 | 2.0 | 5.0 | 2.0 | 5.0 | 4.0 | 2.0 | 25.0 |
| 1 | 4 | 16 | 2 | 4 | 1 | 4 | 10 | 0.5 | 2.5 | 0.5 | 32 | 16 |
| 2 | 4 | 16 | 0.5 | 32 | 0.5 | 2 | 1.2 | 0.5 | 1.2 | 0.25 | 32 | 32 |
| 3 | 4 | 16 | 4 | 1 | 0.25 | 0.5 | 1.2 | 0.5 | 1.2 | 0.12 | 8 | 8 |
| 4 | 4 | 2 | 1 | 8 | 0.25 | 1 | 1.2 | 8 | 2.5 | 0.25 | 16 | 8 |
| 5 | 4 | 2 | 1 | 4 | 0.25 | 1 | 5 | 8 | 2.5 | 0.25 | 16 | 8 |
| 6 | 2 | 16 | 2 | 1 | 0.12 | 0.5 | 0.6 | 0.5 | 1.2 | 0.12 | 0.5 | 2 |
| 7 | 2 | 16 | 4 | 8 | 4 | 16 | 2.5 | 0.5 | 1.2 | 0.25 | 32 | 8 |
| 8 | 2 | 16 | 4 | 4 | 0.06 | 0.25 | 0.6 | 0.5 | 1.2 | 0.12 | 32 | 8 |
| 9 | 4 | 2 | 0.12 | 2 | 0.12 | 0.5 | 0.6 | 0.5 | 2.5 | 0.25 | 32 | 16 |
| 10 | 4 | 16 | 2 | 8 | 0.12 | 0.25 | 1.2 | 0.5 | 2.5 | 0.5 | 8 | 16 |
| 11 | 4 | 16 | 4 | 8 | 0.06 | 0.25 | 1.2 | 0.5 | 1.2 | 0.25 | 32 | 8 |
| 12 | 4 | 16 | 0.25 | 4 | 0.12 | 0.5 | 1.2 | 0.5 | 2.5 | 0.25 | 32 | 16 |
| 13 | 2 | 4 | 0.25 | 8 | 0.12 | 2 | 0.6 | 0.5 | 0.6 | 0.12 | 32 | 8 |
| 14 | 2 | 16 | 4 | 8 | 1 | 4 | 1.2 | 0.5 | 5 | 0.5 | 32 | 16 |
| 15 | 1 | 8 | 16 | 4 | 0.06 | 0.25 | 0.3 | 0.5 | 1.2 | 0.12 | 0.25 | 8 |
| 16 | 2 | 2 | 0.12 | 2 | 0.12 | 0.25 | 1.2 | 0.5 | 1.2 | 0.25 | 0.25 | 16 |
| 17 | 4 | 16 | 8 | 8 | 0.06 | 0.25 | 0.6 | 0.5 | 1.2 | 0.25 | 32 | 16 |
| 18 | 4 | 16 | 4 | 4 | 0.12 | 0.5 | 1.2 | 1 | 1.2 | 0.25 | 32 | 16 |
| 19 | 1 | 16 | 4 | 8 | 0.12 | 0.25 | 0.3 | 0.5 | 1.2 | 0.25 | 32 | 16 |
| 20 | 0.4 | 16 | 1 | 8 | 0.12 | 0.25 | 10 | 2 | 2.5 | 0.25 | 0.25 | 16 |
| 21 | 4 | 16 | 4 | 1 | 0.12 | 0.25 | 1.2 | 0.5 | 1.2 | 0.25 | 32 | 8 |
| 22 | 1 | 16 | 1 | 2 | 0.06 | 0.25 | 0.6 | 0.5 | 2.5 | 0.25 | 0.5 | 8 |
| 23 | 0.4 | 16 | 8 | 1 | 0.12 | 0.5 | 0.6 | 16 | 1.2 | 0.25 | 32 | 16 |
| 24 | 4 | 16 | 2 | 8 | 4 | 8 | 2.5 | 0.5 | 1.2 | 0.25 | 32 | 16 |
| 25 | 2 | 8 | 0.25 | 2 | 0.12 | 0.5 | 0.6 | 0.5 | 1.2 | 0.25 | 0.5 | 16 |
| 26 | 4 | 16 | 1 | 4 | 0.12 | 0.5 | 0.6 | 0.5 | 2.5 | 0.25 | 32 | 8 |
| 27 | 2 | 4 | 0.25 | 8 | 0.06 | 0.25 | 0.6 | 0.5 | 1.2 | 0.25 | 8 | 4 |
| 28 | 4 | 16 | 4 | 8 | 0.12 | 0.5 | 0.6 | 0.5 | 0.6 | 0.12 | 32 | 4 |
| 29 | 0.4 | 16 | 4 | 2 | 1 | 2 | 20 | 0.5 | 0.6 | 0.25 | 4 | 2 |
| 30 | 2 | 16 | 4 | 1 | 0.12 | 0.25 | 1.2 | 0.5 | 2.5 | 0.12 | 0.5 | 4 |
| 31 | 2 | 16 | 0.5 | 4 | 0.12 | 0.25 | 1.2 | 0.5 | 1.2 | 0.25 | 32 | 16 |
| 32 | 2 | 16 | 8 | 1 | 0.12 | 0.5 | 1.2 | 0.5 | 1.2 | 0.25 | 32 | 4 |
| 33 | 1 | 16 | 2 | 0.5 | 0.06 | 0.25 | 0.3 | 0.5 | 0.6 | 0.12 | 0.5 | 2 |
| 34 | 2 | 16 | 16 | 4 | 4 | 8 | 2.5 | 0.5 | 1.2 | 0.25 | 16 | 4 |
| 35 | 2 | 16 | 4 | 2 | 0.06 | 0.25 | 0.6 | 1 | 0.6 | 0.25 | 2 | 4 |
| 36 | 1 | 16 | 16 | 4 | 0.12 | 0.25 | 0.6 | 1 | 0.6 | 0.12 | 32 | 8 |
| 37 | 2 | 16 | 16 | 4 | 0.06 | 0.25 | 0.3 | 0.5 | 0.6 | 0.12 | 0.5 | 2 |
| 38 | 4 | 16 | 0.25 | 8 | 1 | 4 | 0.6 | 0.5 | 40 | 16 | 32 | 16 |
| 39 | 4 | 16 | 4 | 4 | 0.12 | 0.5 | 0.6 | 0.5 | 2.5 | 0.25 | 32 | 16 |
| 40 | 2 | 2 | 0.12 | 2 | 0.12 | 0.5 | 2.5 | 0.5 | 1.2 | 0.25 | 32 | 16 |
| 41 | 1 | 8 | 0.12 | 1 | 0.06 | 0.25 | 2.5 | 0.5 | 0.6 | 0.12 | 0.25 | 8 |
| 42 | 1 | 16 | 2 | 4 | 0.06 | 0.25 | 0.3 | 0.5 | 1.2 | 0.12 | 0.25 | 2 |
| 43 | 0.4 | 16 | 8 | 4 | 8 | 16 | 5 | 0.5 | 1.2 | 0.25 | 32 | 8 |
| Drug-resistant isolates(n) | 43 | 43 | 32 | 13 | 8 | 7 | 3 | 3 | 1 | 1 | 9 | 1 |
| b | |||||
|---|---|---|---|---|---|
| No. of strains | Mfx | Lfx | Km | Ak | |
| Pre-XDR | 1 | R | S | S | S |
| 6 | R | R | S | S | |
| 0 | S | R | S | S | |
| XDR | 1 | R | R | R | R |
CCs critical concentrations
XDR Extensively drug- resistant tuberculosis