Table 4.
Genotypic resistance of 43 phenotypic MDR strains to second-line anti-TB drugs
| Drug | Resistance phenotype (No. of strains) | Resistance genotype | MIC (µg/mL) | Total | ||
|---|---|---|---|---|---|---|
| Gene | Mutations | No. of strains | ||||
| LFX | Resistant (7) | gyrA | A90V | 2 | 4 | 5/7 |
| D94A | 1 | 16 | ||||
| D94G | 1 | 16 | ||||
| D94H | 1 | 8 | ||||
| Susceptible (36) | gyrA | D94G | 1 | 0.5 | 1/36 | |
| MFX | Resistant (8) | gyrA | A90V | 2 | 1 | 6/8 |
| D94A | 1 | 1 | ||||
| D94G | 1 | 4 | ||||
| D94H | 1 | 4 | ||||
| gyrb | S447F | 1 | 1 | 1/8 | ||
| Susceptible (35) | gyrA | D94G | 1 | 0.12 | 1/35 | |
| Ak | Resistant (1) | rrs | A1401G | 1 | 16 | 1/1 |
| Susceptible (42) | rrs | C517T | 1 | 0.25 | 1/42 | |
| Km | Resistant (1) | rrs | A1401G | 1 | 40 | 1/1 |
| Susceptible (42) | rrs | C517T | 1 | 1.2 | 1/42 | |
| Eto | Resistant (3) | fabG1-inhA | C8T | 1 | 10 | 3/3 |
| C15C | 2 | 20 | ||||
| Susceptible (40) | fabG1-inhA | C15C | 1 | 5 | 1/40 | |
| Pas | Resistant (3) | folC | 143 T | 1 | 16 | 1/3 |
| Susceptible (40) | folC | S150G | 1 | 1 | 1/40 | |