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. 2022 May 26;13:212. doi: 10.1186/s13287-022-02891-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — In vivo Musashi-1 downregulation limits tumor growth. A Xenograft tumor growth over time in Msi-1-siRNA and control siRNA-treated mice (p < 0.05 after day 24: p = 0.038 at d (day) 24, p = 0.048 at d 28, p = 0.041 at d 31, p = 0.032 at d 35, p = 0.047 at d 38, n = 15). B TERT (telomerase) mRNA expression in Msi-1 depleted tumors compared to controls (p = 0.001, n = 27 for ctrl (mean delta ct value 8.43), n = 21 for Msi-1 KD (mean delta ct value 10.37)). C Dead cell (C1) and mitotic cell (C2) area in Msi-1 depleted tumors compared to controls (n = 14). D Representative pictures of control (left) and Msi-1 depleted (right) tumor microsections after immunofluorescence staining (DNA = blue, mitotic activity = green, dead cells = red)