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. 2022 May 26;12:72. doi: 10.1186/s13578-022-00800-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — B6.EDA^+/+ mice have elevated IOP, RGC loss, and ON damage. A IOP is significantly elevated in B6.EDA^+/+ mice (n = 16) compared to C57BL/6J (n = 22) at 12 months of age, mean ± SEM. Significance determined by Student’s t-test. B B6.EDA^+/+ mice (n = 10) have 9.7% loss of RGCs at 12 months of age compared to C57BL/6J (n = 15) as quantified by RBPMS stained retinal flat mounts. Significance determined by Student’s t-test (C) Percent of axons with no damage [1] or with mild damage (2) in transverse sections of optic nerves in B6.EDA^+/+ (n = 23) and C57BL/6J (n = 18) mice. B6.EDA^+/+ have significantly more ON damage compared to C57BL/6J, Significance determined by Fisher's exact test. D Images of representative transverse sections of optic nerves of B6.EDA^+/+ and C57BL/6J mice. * = p < 0.05, **** = p < 0.0001