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. 2022 May 27;19:122. doi: 10.1186/s12974-022-02474-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Role of microglial Sirt3 in anti-inflammatory effects of IF at day 3 after ICH. A Examples of Iba-1 immunohistochemistry in the ipsilateral basal ganglia ICH, Scale bar = 50 μm. B The number of Iba-1⁺ cells was quantified as shown in the bar graphs. mRNA levels of IL-1β C and TNF-α D in microglia isolated from ipsilateral cerebra were measured by qRT-PCR. Secretion of IL-1β E and TNF-α F in blood after ICH was measured by ELISA. G Western blot analysis of CD16 and CCL3 protein levels in microglia isolated from ipsilateral basal ganglia and quantification of relative gray value of CD16 H and CCL3 I protein bands. Statistical analysis was performed using Student t test. Values are mean ± SD, ^#P < 0.05 compared with Sirt3^f/f group