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. 2022 May 27;22:147. doi: 10.1186/s12866-022-02557-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The beta diversity analysis of microbiota in Bile juice collected from gallbladder. Microbiota beta diversity in bile collected from resected gallbladders in pancreaticobiliary tract and gallbladder cancers. The beta diversity analysis at the genus level of 16S rRNA gene amplicon sequencing pattern by NMDS (A) and PCoA (B) among the lesion locations or lesion type. The type of cancer includes pancreatic ductal adenocarcinoma (PDAC), cholangiocarcinoma (BDAC) and gallbladder cancer (GDAC). The type of cystic is a pancreas cystic lesion. Dim, dimension; N, trends in these variances with the N-score of TNM classification; M, trends in these variances with the M-score of TNM classification; NMDS, Non-metric multidimensional scaling; PCoA, principal coordinate analysis