Table 3.

Multivariate or Univariate Cox regression analysis each microbiota

1. Totall (n = 219, Death:69)*a	Univariate			Multivariate
microbe	Z-score	p value		Z-score	p value
Abiotrophia	2.180	0.029	*	2.757	0.006	**
Amaricoccus	4.735	<0.001	***	4.497	<0.001	***
Blastococcus	3.239	0.001	**	3.668	<0.001	***
Bosea	3.239	0.001	**	3.668	<0.001	***
Delftia	2.374	0.018	*	2.965	0.003	**
Desulfovibrio	2.016	0.044	*	1.139	0.255
Dokdonella	3.239	0.001	**	3.668	<0.001	***
Enterococcus	2.299	0.022	*	1.087	0.277
Flavobacterium	3.737	<0.001	***	3.608	<0.001	***
Gemella	2.290	0.022	*	3.169	0.002	**
Granulicatella	2.087	0.037	*	1.975	0.048	*
Haemophilus	2.805	0.005	**	2.480	0.013	*
Lawsonella	1.876	0.061		3.754	<0.001	***
Leucobacter	3.025	0.002	**	3.351	0.001	***
Pelagibacterium	3.418	0.001	***	2.563	0.010	*
Robinsoniella	2.054	0.040	*	1.150	0.250
Sphingopyxis	3.418	0.001	***	2.563	0.010	*
Staphylococcus	0.253	0.801		2.645	0.008	**
Streptococcus	−2.138	0.033	*	−2.042	0.041	*
Williamsia	2.079	0.038	*	2.020	0.043	*
2. Bile Duct lesion (n = 92, Death:18)*b	Univariate			Multivariate
microbe	Z-score	p value		Z-score	p value
Delftia	2.896	0.004	**	2.580	0.010	**
Dermacoccus	2.612	0.009	**	2.363	0.018	*
Haemophilus	2.838	0.005	**	2.786	0.005	**
Lawsonella	1.473	0.141		2.549	0.011	*
Leucobacter	3.351	0.001	***	3.572	<0.001	***
Methylorosula	2.114	0.035	*	2.332	0.020	*
Parabacteroides	2.114	0.035	*	1.360	0.174
Raoultella	1.194	0.232		2.138	0.032	*
Robinsoniella	2.114	0.035	*	1.360	0.174
Staphylococcus	3.643	<0.001	***	3.458	0.001	***
3. Pancreas lesion (n = 100, Death:43)*c	Univariate			Multivariate
microbe	Z-score	p value		Z-score	p value
Abiotrophia	1.977	0.048	*	2.428	0.015	*
Akkermansia	0.124	0.902		2.032	0.042	*
Alloprevotella	2.162	0.031	*	1.641	0.101
Aureimonas	2.852	0.004	**	2.125	0.034	*
Citrobacter	1.343	0.179		1.983	0.047	*
Flavobacterium	3.126	0.002	**	2.780	0.005	**
Gemella	2.148	0.032	*	3.074	0.002	**
Granulicatella	2.140	0.032	*	1.709	0.088
Howardella	2.698	0.007	**	1.974	0.048	*
Hungatella	1.851	0.064		3.026	0.002	**
Klebsiella	2.690	0.007	**	2.484	0.013	*
Lawsonella	1.708	0.088		2.273	0.023	*
Novosphingobium	2.458	0.014	*	0.178	0.859
Ochrobactrum	2.698	0.007	**	1.974	0.048	*
Pelagibacterium	2.852	0.004	**	2.125	0.034	*
Pseudomonas	−0.947	0.343		−2.269	0.023	*
Sphingopyxis	2.852	0.004	**	2.125	0.034	*
Williamsia	2.835	0.005	**	2.124	0.034	*

^aMultivariate cox regression alaysis with ASA score, age, sex, and preoperative chemotherapy

^bMultivariate cox regression alaysis with ASA score and the presence of lymph node metastasis

^cMultivariate cox regression alaysis with ASA Score, Age, Sex, the presence of lymph node metastasis, and preoperative chemotherapy. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001