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. 2022 May 12;13(2):19476035221077401. doi: 10.1177/19476035221077401

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — EV miR-26a-5p promoted chondrocyte proliferation and migration through mediating PTEN. (A-B) PTEN expression in chondrocytes after treatment with inhibitor-NC-Hypo-EVs or miR-inhibitor-Hypo-EVs. (C-D) PTEN expression in chondrocytes after sh-NC or sh-PTEN transfection. (E-F) After transfection with sh-NC or sh-PTEN and administration of inhibitor-NC-Hypo-EVs or miR-inhibitor-Hypo-EVs, the expression level of PTEN was measured in chondrocytes. (G-I) CCK-8, EdU, and transwell assays were applied to evaluate cell proliferation and migration. EVs = extracellular vehicles; PTEN = phosphatase and tensin homolog; NC = negative control; CCK-8 = cell counting kit-8; EdU = 5-Ethynyl-2’-Deoxyuridine; DAPI = 4’,-6-diamidino-2-phenylindole. *P < 0.05, **P < 0.01.