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. 2022 Apr 19;13(2):19476035221093060. doi: 10.1177/19476035221093060

Figure 4.

Figure 4.

LIPUS enhances the anti-degeneration effects of MSCs on OA chondrocytes by promoting exosome release. (A) The OA chondrocyte and BMSC co-culture system was stimulated by LIPUS. (B) Immunohistochemical staining (ICC) and toluidine blue staining in OA chondrocytes. (C, D) Western blotting analysis of COL2, AGG, and β-actin expressions in OA chondrocytes. LIPUS = low-intensity pulsed ultrasound; MSCs = mesenchymal stem cells; OA = osteoarthritis; BMSC = bone marrow-derived MSC; COL2 = type II collagen; AGG = aggrecan. The values are the mean ± SD; n = 3, *P < .05.