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. 2022 Apr 19;13(2):19476035221093060. doi: 10.1177/19476035221093060

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — LIPUS enhances the repair effects of MSCs on OA cartilage through the exosome release pathway. (A) The femoral condylar cartilage was observed and detected through safranin-O/fast green staining; scale bars = 2,000 μm, 200 μm. (B) Bar graph comparing the Mankin scores. (C, D) Western blotting analysis of COL2, AGG, and β-actin expressions in the cartilage. LIPUS = low-intensity pulsed ultrasound; MSCs = mesenchymal stem cells; OA = osteoarthritis; COL2 = type II collagen; AGG = aggrecan. The values are the mean ± SD; n = 6, *P < .05.