Table 6.

Mediation effect of obesity on the relationship between age at menarche and blood pressure in women (N=4513)

Path		Model 1*			Model 2†			Model 3‡			Model 4§			Model 5¶
		β	B (95% CI)	P value	β	B (95% CI)	P value	β	B (95% CI)	P value	β	B (95% CI)	P value	β	B (95% CI)	P value
1	Menarche age→BMI	−0.1080	−0.2045 (−0.2595 to −0.1496)	<0.001	−0.0725	−0.1374 (−0.1930 to −0.0818)	<0.001	−0.0707	−0.1339 (−0.1892 to −0.0786)	<0.001	−0.0705	−0.1334 (−0.1880 to −0.0788)	<0.001	−0.0468	−0.0885 (−0.1409 to −0.0361)	<0.001
	Menarche age→DBP	−0.0367	−0.2096 (−0.3731 to −0.0461)	0.0120	−0.0454	−0.2596 (−0.4268 to −0.0924)	0.0024	−0.0433	−0.2475 (−0.4145 to −0.0806)	0.0037	−0.0447	−0.2542 (−0.4213 to −0.0872)	0.0029	−0.0379	−0.2154 (−0.3833 to −0.0474)	0.0120
	BMI→DBP	0.2171	0.6545 (0.5682 to 0.7408)	<0.001	0.2241	0.6757 (0.5881 to 0.7634)	<0.001	0.2276	0.6835 (0.5955 to 0.7715)	<0.001	0.2208	0.6643 (0.5746 to 0.7541)	<0.001	0.1986	0.5973 (0.5026 to 0.6921)	<0.001
	Total effect	−0.0601	−0.3435 (−0.5099 to −0.177)	<0.001	−0.0617	−0.3524 (−0.5234 to −0.1815)	<0.001	−0.0593	−0.3390 (−0.5098 to −0.1683)	<0.001	−0.0602	−0.3429 (−0.5133 to −0.1724)	<0.001	−0.0471	−0.2682 (−0.4388 to −0.0976)	0.0021
2	Menarche age→BMI	0.1085	−0.2051 (−0.2601 to −0.1502)	<0.001	−0.0731	−0.1381 (−0.1936 to −0.0826)	<0.001	−0.0712	−0.1346 (−0.1898 to −0.0793)	<0.001	−0.0711	−0.1342 (−0.1887 to −0.0797)	<0.001	−0.0473	−0.0892 (−0.1416 to −0.0369)	<0.001
	Menarche age→SBP	−0.0004	−0.0046 (−0.3619 to 0.3526)	0.9797	−0.0477	−0.585 (−0.9350 to −0.2351)	0.0011	−0.0466	−0.5711 (−0.9209 to −0.2213)	0.0014	−0.0486	−0.5957 (−0.9468 to −0.2446)	<0.001	−0.0446	−0.5479 (−0.9025 to −0.1932)	0.0025
	BMI→SBP	0.1289	0.8359 (0.6469 to 1.0249)	<0.001	0.1685	1.0927 (0.9088 to 1.2766)	<0.001	0.1682	1.0905 (0.9058 to 1.2753)	<0.001	0.1585	1.0286 (0.8395 to 1.2176)	<0.001	0.1441	0.9366 (0.7361 to 1.1371)	<0.001
	Total effect	−0.0144	−0.1761 (−0.5342 to 0.182)	0.3350	−0.0601	−0.736 (−1.0902 to −0.3817)	<0.001	−0.0586	−0.7178 (−1.0719 to −0.3638)	<0.001	−0.0599	−0.7337 (−1.0883 to −0.3791)	<0.001	−0.0515	−0.6314 (−0.9889 to −0.2739)	<0.001
3	Menarche age→WC	−0.0837	−0.4928 (−0.6642 to −0.3213)	<0.001	−0.0910	−0.5355 (−0.7107 to −0.3602)	<0.001	−0.0896	−0.5275 (−0.7024 to −0.3526)	<0.001	−0.0898	−0.5285 (−0.7026 to −0.3545)	<0.001	−0.0696	−0.4085 (−0.5778 to −0.2392)	<0.001
	Menarche age→DBP	−0.0454	−0.2589 (−0.4232 to −0.0945)	0.0020	−0.0456	−0.26 (−0.4288 to −0.0912)	0.0025	−0.0437	−0.2491 (−0.4178 to −0.0805)	0.0038	−0.0452	−0.2571 (−0.4257 to −0.0884)	0.0028	−0.0373	−0.2118 (−0.3811 to −0.0424)	0.0143
	WC→DBP	0.1789	0.1733 (0.1454 to 0.2013)	<0.001	−0.1810	0.1754 (0.1473 to 0.2034)	<0.001	0.1787	0.1732 (0.1451 to 0.2013)	<0.001	0.1705	0.1647 (0.1363 to 0.1931)	<0.001	0.1445	0.1399 (0.1104 to 0.1695)	<0.001
	Total effect	−0.0604	−0.3443 (−0.5107 to −0.1779)	<0.001	−0.0620	−0.3539 (−0.5248 to −0.183)	<0.001	−0.0597	−0.3405 (−0.5112 to −0.1698)	<0.001	−0.0606	−0.3441 (−0.5145 to −0.1737)	<0.001	−0.0474	−0.2689 (−0.4395 to −0.0984)	0.0020
4	Menarche age→WC	−0.0849	−0.4944 (−0.6658 to −0.323)	<0.001	−0.0914	−0.5376 (−0.7129 to −0.3624)	<0.001	−0.0901	−0.5299 (−0.7048 to −0.355)	<0.001	−0.0904	−0.531 (−0.7051 to −0.357)	<0.001	−0.0702	−0.411 (−0.5803 to −0.2417)	<0.001
	Menarche age→SBP	0.0004	0.0044 (−0.3439 to 0.3526)	0.9804	−0.0468	−0.5643 (−0.9094 to −0.2192)	0.0014	−0.0459	−0.5533 (−0.8983 to −0.2082)	0.0017	−0.0481	−0.5792 (−0.9255 to −0.233)	0.0010	−0.0433	−0.5228 (−0.8721 to −0.1735)	0.0034
	WC→SBP	0.1772	0.3632 (0.3040 to 0.4224)	<0.001	0.1574	0.3226 (0.2652 to 0.38)	<0.001	0.1538	0.3151 (0.2576 to 0.3727)	<0.001	0.1436	0.2942 (0.2358 to 0.3526)	<0.001	0.1290	0.2655 (0.2045 to 0.3266)	<0.001
	Total effect	−0.0145	−0.1752 (−0.5277 to 0.1773)	0.3300	−0.0612	−0.7377 (−1.086 to −0.3894)	<0.001	−0.0598	−0.7202 (−1.0683 to −0.3722)	<0.001	−0.0611	−0.7354 (−1.084 to −0.3869)	<0.001	−0.0524	−0.6320 (−0.9832 to −0.2807)	<0.001

Path 1: mediation effect of BMI on the relationship between age at menarche and DBP.

Path 2: mediation effect of BMI on the relationship between age at menarche and SBP.

Path 3: mediation effect of WC on the relationship between age at menarche and DBP.

Path 4: mediation effect of WC on the relationship between age at menarche and SBP.

*Unadjusted.

†Adjusted for age, educational attainment, marital status and region.

‡Adjusted for age, educational attainment, marital status, region, cigarette smoking, alcohol consumption, eating habits, entertainment, the experience of a traumatic event and physical activity.

§Adjusted for age, educational attainment, marital status, region, cigarette smoking, alcohol consumption, eating habits, entertainment, the experience of a traumatic event, physical activity, history of CVDs, hepatitis history, history of antilipidaemic medication and history of antidiabetic medication.

¶ Adjusted for age, educational attainment, marital status, region, cigarette smoking, alcohol consumption, eating habits, entertainment, the experience of a traumatic event, physical activity, history of CVDs, hepatitis history, history of antilipidaemic medication, history of antidiabetic medication, LDL-C, HDL-C, TG, HbA1c, Scr and SUA.

B, unstandardised coefficient; BMI, body mass index; CVD, cardiovascular disease; DBP, diastolic blood pressure; HbA1c, haemoglobin A1C; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; SBP, systolic blood pressure; Scr, serum creatinine; SUA, serum uric acid; TG, triglyceride; WC, waist circle; β, standardised coefficient.