Table 1.

Gene-expression analysis for MYC/BCL2 double-high expression (DhE) in DLBCL within the EZB genetic subset and LymphGen-unclassified cases (false discovery rate 0.10)

Gene-expression in DhE compared with non-DhE
In the EZB subset
Gene name	Downregulated: CLECL1, GZMK, TRBC1, SH3BGRL3, IL10RA, PFN1, DENND4B, RGS1, HLA-B, RASSF2, UHMK1, B2M, SCAMP2, COMMD3, RNF19A, NRBP1, BCL11B, BTN3A1, HLA-F, HLA-E, RASAL3, ANKRD12, USP32, CEBPG, MKRN1, UBXN4, MPPE1, LCP2, BTN2A2, CALM2, CLIP4, ATXN7, CHIC1, CPEB2, STAMBPL1, RFFL, SLC4A1AP, CSNK1D, NBR1, IDS, CD84, TFPT, ZCCHC6, GTDC1, AKAP13, CYLD, ASXL2, CHTOP, TDRD3, TGOLN2, AAK1, LOC401320
Gene category of GO terms	GO Biological Process: "antigen presentation\, endogenous antigen″, "antigen processing\, endogenous antigen via MHC class I″, "antigen presentation″, "antigen processing", "defense response″, "response to biotic stimulus″, "immune response″, "response to external stimulus″ GO Cellular Component: "membrane″, "cell″ GO Molecular Function: "MHC class I receptor activity″, "receptor activity″
In LymphGen-unclassified cases
Gene name	Upregulated, fold change ≥1.5: MYC, KIAA0226L, PMAIP1, CLECL1, FUT8, PUS7, PIGW, TMEM97, BCL2, HIST1H2AC, ADTRP, ZNF385C, MRPL3, FABP5, IGF2BP3, SNHG1, CCDC86, NOC3L, P2RX5, CYB5R2, RPL17, EBNA1BP2, FOXC1, CCDC113, ZNF260, ZNF320, ARHGAP24, SPIB, PSORS1C2, NOL11, SLC25A32, DBN1, NOP2, DCTPP1, GCSH, GAS5, ZNF587B, PDCD2L, TMCC3, GAR1, TRIT1, BTBD19, LOC101928702, FSTL5, VSNL1, POLR3G, NME2, CISD1, DDX21, C10orf2, IPO4, C12orf45, POLR1D, APEX1, DIRF-AS1, MRPS33, GPX7, RUVBL2, PRMT5, POLR2H, MAT2A, ZNF639, NPM3, TEX10, IER3IP1, CDC123, PLEKHJ1, LYAR, BMF, ATP5G1, EME1, TOMM40, PSME3, ZNF784, NAT9, C7orf41, SNHG8, TCTN3, ZNF480, CLPX, LOC100507388, MSRB1, PNP, PLIN1, TIMM10B
Gene category of GO terms	GO Biological Process: "rRNA metabolism″, "RNA metabolism″, "ribosome biogenesis″, "ribosome biogenesis and assembly″, "RNA processing″, "rRNA processing″, "cell growth and/or maintenance″ GO Cellular Component: "nucleolus″, "mitochondrion", "intracellular", "mitochondrial membrane", "RNA polymerase complex", "mitochondrial inner membrane", "inner membrane", "cytoplasm", "outer membrane", "organellar ribosome", "mitochondrial ribosome", "nucleus", "DNA-directed RNA polymerase I complex", "proteasome complex (sensu Eukarya)" GO Molecular Function: "DNA-directed RNA polymerase activity", "RNA binding", "nucleotidyltransferase activity", "transferase activity", "lipid binding", "nucleic acid binding"

Abbreviation: GO, Gene Oncology.

Enriched Go categories were identified by Expression Analysis Systematic Explorer (EASE, A desktop version of DAVID) with EASE scores <0.05.