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. 2022 May 13;13:891456. doi: 10.3389/fimmu.2022.891456

Figure 1.

Figure 1

Analysis of IL-6 signalling biomarkers. (A) Serum levels of IL-6, sIL-6R and sgp130, and Binary/Ternary complex ratio (B/T) and fold molar excess of sgp130 over sIL-6R (FME) in moderate (n = 257), severe survivors (n = 40) and severe non-survivors (exitus) (n = 69) hospitalized COVID-19 patients. Box plots showed median with upper and lower quartiles. The whiskers show Tukey confidence intervals. (B) Correlation matrix of IL-6 signalling variables assessed using Spearman’s Rho analysis. Statistically significant results are shown with the corresponding correlation coefficients. Binary/Ternary complex ratio (B/T); Fold molar excess of sgp130 over sIL-6R (FME). *p < 0.05; **p < 0.01; ***p < 0.001; “X” no statistical significance.