Table 3A.
Univariate logistic regression analyses of IL-6 signalling biomarkers as predictors of COVID-19 mortality.
| Variable | Risk factor cut-off characterization | Cut-off univariate logistic | |||||
|---|---|---|---|---|---|---|---|
| Cut-off | Sensitivity % | Specificity % | PPV % | NPV % | O.R. | 95% CI | |
| IL-6 (pg/mL) | ≥ 27.40 | 79.40 | 50.04 | 73.00 | 58.81 | 3.86 | (1.64-9.06)* |
| sIL-6R (ng/mL) | ≤ 34.49 | 54.44 | 79.49 | 82.27 | 50.04 | 4.63 | (1.86-11.51)*** |
| sgp130 (ng/mL) | ≤ 367.51 | 30.96 | 92.30 | 87.56 | 43.46 | 5.36 | (1.48-19.39)*** |
| B/T | ≤ 1.561 | 47.11 | 84.67 | 88.93 | 49.37 | 6.05 | (2.11-17.33)** |
| FME | ≥ 2.869 | 64.74 | 65.18 | 75.93 | 51.05 | 3.27 | (1.44-7.45)** |
| Lymphocytes (x 10^3/µL) | ≤ 0.565 | 39.39 | 90.00 | 62.26 | – | 5.96 | (2.30-15.41)*** |
| Creatinine (U/L) | ≥ 1.15 | 57.35 | 81.58 | 84.78 | 51.67 | 5.85 | (1.86-18.38)** |
| Troponine (ng/mL) | ≥ 12.05 | 84.44 | 56.25 | 84.44 | 19.15 | 6,98 | (1.95-24.98)** |
| Ferritine (ng/mL) | ≥ 992.75 | 76.59 | 45.95 | 64.29 | 32.08 | 2.78 | (1.09-7.09)** |
NPV, Negative predictive value; PPV, Positive predictive value; B/T, Binary/ternary complex ratio; FME, Fold molar excess of sgp130 over sIL-6R; O.R., Odds ratio. *p < 0.05, **p < 0.01, ***p < 0.001.