Table 3B.
Multivariate logistic regression analyses of IL-6 signalling biomarkers as predictors of COVID-19 mortality.
| Variable | O.R. | 95% CI | O.R. | 95% CI | O.R. | 95% CI | O.R. | 95% CI | O.R. | 95% CI |
|---|---|---|---|---|---|---|---|---|---|---|
| IL-6 ≥ 27.40 pg/mL | 2.42 | (0.96-6.01) | 3.69 | (1.33-10.28)* | 4.08 | (1.62-10.3)** | 4.05 | (1.30-12.61)* | – | – |
| sIL-6R ≤ 34.49 ng/mL | 3.91 | (1.39-11)** | – | – | – | – | – | – | – | – |
| sgp130 ≤ 367.51 ng/mL | 2.02 | (0.48-8.43) | – | – | – | – | – | – | – | – |
| B/T ≤ 1.561 | – | – | – | – | – | – | – | – | 5.85 | (1.82-18.81)** |
| FME ≥ 2.869 | – | – | – | – | 3.67 | (1.50-9)** | 4.39 | (1.51-12.71)** | – | – |
| Lymphocytes ≤ 0.565 x 10^3/µL | – | – | 5.02 | (2.43-19.86)*** | 6.71 | (1.60-28.10)** | 4.87 | (1.37-17.29)** | ||
| Creatinine ≥ 1.15 U/L | – | – | 6.95 | (1.49-18.17)* | 6.78 | (2.17-21.11)** | 7.38 | (2.49-21.92)*** |
NPV, Negative predictive value; PPV, Positive predictive value; B/T, Binary/ternary complex ratio; FME, Fold molar excess of sgp130 over sIL-6R; O.R., Odds ratio. *p < 0.05, **p < 0.01, ***p < 0.001.