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. 2022 May 23;11(5):1029. doi: 10.3390/antiox11051029

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Control group (A) high power view shows average glomeruli with average Bowman’s spaces, average proximal tubules with preserved brush borders (black arrow), average distal tubules, and average interstitium (H&E); Dox group (B) showing focal cystic dilation of renal tubules with focal interstitial nephritis (H&E); Dox + H group (C) showing apparently normal renal cortex with few tubules containing renal cast (arrow) (H&E); (D) (Dox + R), showing some degenerating renal tubules (H&E); Dox + P group (E) showing apparently normal renal medulla (H&E); Dox + H + R + P group (F) showing apparently normal renal cortex (H&E).