Table 1.
Iron values in normal and hemochromatosis human and mouse samples.
| Iron | Normal | Hemochromatosis |
|---|---|---|
| Human Serum | 0–14 year old: 16–128 µg/dL [26] |
HFE-hemochromatosis 212.65 ± 30.82 mg/dL [27] |
| 14–19 year old: 31–168 µg/dL (Male), 20–162 µg/dL (Female) [26] |
Hemojuvelin-hemochromatosis 225–315 μg/dL [28] |
|
| Adults: 50–150 µg/dL or 9–27 μmol/L [29] |
Hepcidin/Ferroportin-hemochromatosis 284 μg/dL [30] |
|
| Human Liver | 0.2–2 mg/g or 3.6–36 μmol/kg [31] |
HFE-hemochromatosis 20 mg/g [31] |
| Hemojuvelin-hemochromatosis 411–429 μmol/g [28] | ||
| Hepcidin/Ferroportin-hemochromatosis 200–500 μmol/g [32] | ||
| Human Brain | Quantitative susceptibility mapping (parts per million, PPM) [33] Caudate: 0.108 ± 0.002 Putamen: 0.095 ± 0.002 Pallidum: 0.190 ± 0.003 Cortex: 0.041 ± 0.001 |
HFE-hemochromatosis Quantitative susceptibility mapping (parts per million, PPM) [33] Caudate: 0.108 ± 0.002 Putamen: 0.104 ± 0.003 * Pallidum: 0.187 ± 0.004 Cortex: 0.042 ± 0.001 |
| Putamen: [34] 50–59 years: 777 ± 267 μg/g 80–89 years: 1155 ± 363 μg/g | ||
| Globus pallidus: [34] 50–59 years: 577 ± 266 μg/g 80–89 years: 1062 ± 526 μg/g | ||
| Caudate nucleus: [34] 50–59 years: 533 ± 268 μg/g 80–89 years: 743 ± 360 μg/g | ||
| Human Retina | 0–35 years: 76.5 ± 9.15 µg/g [35] >65 years: 116 ± 9.73 µg/g [35] |
|
| Mouse Serum | 10 week old: 291 ± 9 μg/dl [36] |
HFE-hemochromatosis 323 ± 24 μg/dL [36] |
| 14 week old: 26.20 ± 1.597 μmol/L [37] |
Hemojuvelin-hemochromatosis 48.50 ± 1.682 μmol/L [37] |
|
| 24 week old: 34.9 ± 8.7 μmol/L [38] |
Hepcidin/Ferroportin-hemochromatosis 39 ± 10 μmol/L [39] |
|
| Mouse Liver | 10 week old: 255 ± 23 μg/dL [36] |
HFE-hemochromatosis 2071 ± 450 μg/dL [36] |
| ≤6 months: 50.6 ± 1.66 μg/g [40] |
Hemojuvelin-hemochromatosis 6070 ± 411.3 μg/g [37] |
|
| ≥16 months: 65.6 ± 2.35 μg/g [40] |
Hepcidin/Ferroportin-hemochromatosis 1119 ± 176 μg/mg [38] |
|
| Mouse Lung | 36 week old: ~0.6 μmolg [41] |
HFE-hemochromatosis ~0.9 μmol/g [41] |
| 25–35 week old: 90–100 μg/g [42] |
Hepcidin-hemochromatosis ~400 μg/g [42] |
|
| 36 week old: ~250 μg/g [43] |
Ferroportin-hemochromatosis ~2300 μg/g [43] |
|
| Mouse Heart | 1 month old: ~30 μg/g [44] |
HFE-hemochromatosis ~75 μg/g [44] |
| 2.5 month old: ~5 μmol/g [45] |
Hemojuvelin-hemochromatosis ~20 μmol/g [45] |
|
| 12 months old: ~50 μg/g [44] |
Ferroportin-hemochromatosis ~9 ng/mg [38] |
* indicates p < 0.05.