Table 6.

Myocardial hydroxyproline (HOP) concentration and left ventricular morphometric parameters.

	C (n = 10)	C + DAPA (n = 10)	DM (n = 10)	DM + DAPA (n = 10)
HOP (mg/g tissue)	1.43 ± 0.35	1.56 ± 0.54	1.48 ± 0.28	1.50 ± 0.28
ICF (%)	9.41 ± 0.02	8.30 ± 0.02	8.85 ± 0.02	9.88 ± 0.02
Diameter (μm)	17.6 (16.7–18.3)	15.5 (15.1–16.3) *	17.1 (15.6–17.8)	17.6 (15.8–18.1)

Data are expressed as mean ± standard deviation or median and 25th and 75th percentiles. C: control; C + DAPA: control treated with dapagliflozin; DM: diabetes mellitus; DM + DAPA: DM treated with dapagliflozin; ICF: myocardial interstitial collagen fraction; Diameter: myocyte lower diameter. ANOVA for a 2 × 2 factorial design and Tukey or Kruskal–Wallis and Dunn; * p < 0.05 vs. C.