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Synthetic scheme for the production of (Z)-5-(substituted benzylidene)-3-phenyl-2-thioxothiazolidin-4-one ((Z)-BPTT) analogs 1–13. Reagents and conditions: (a) Et3N, CH2Cl2, RT, 2 d, yield 41%; (b) NaOAc, CH3CO2H, reflux, 1–7 h, yield 73–90% for analogs 1–2 and 4–13, and piperidine, EtOH, reflux, 4 h, yield 30% for analog 3.
