Table 1.

The role of selenium in animal models.

Component	Animal	Model	Route of Administration	Main Outcome	Ref
Sodium selenite	Rats	High-fat diet induced hyperlipidemic	Oral administration	Attenuated liver steatosis	[47]
Sodium selenite	Mice	Carbon tetrachloride (CCl4) induced hepatic fibrosis	Intraperitoneal injection	Decreased hepatic fibrosis after CCl4	[55]
Selenium-enriched green tea	Mice	Carbon tetrachloride (CCl4) induced hepatic fibrosis	Oral administration	Improved liver fibrosis	[56]
Selenium-glutathione-enriched probiotics	Rats	Carbon tetrachloride (CCl4) induced hepatic fibrosis	Oral administration	Attenuated liver fibrosis	[58]
Selenium and vitamin E	Rats	Carbon tetrachloride (CCl4) induced hepatic fibrosis	Oral administration	Decreased the degree of hepatic fibrosis and promote the recovery process	[59]
Selenium and vitamin E	Rats	Carbon tetrachloride (CCl4)/ethanol-induced cirrhosis	Oral administration	Decreased the amount of hepatic fibrosis	[61]
Sodium selenite	Rats	Thioacetamide induced cirrhosis	Intraperitoneal injection	Attenuated liver cirrhosis.	[62]
Sodium selenite	Mice	Thioacetamide induced cirrhosis	Oral administration Intraperitoneal injection	Could not restore hepatic glutathione peroxidase	[63]
Sodium selenite	Rats	Diethylnitrosamin (DEN) induced hepatocellular carcinoma	Oral administration	Accelerated the growth of hepatocellular carcinoma	[67]
Selenium	Mice	Carbon tetrachloride (CCl4) induced hepatocellular carcinoma	Oral administration	Protected against liver damage	[69]